A novel intravitreal fluocinolone acetonide implant (Iluvien(®)) in the treatment of patients with chronic diabetic macular edema that is insufficiently responsive to other medical treatment options: a case series.

Iluvien (®) is a novel, nonbiodegradable, sustained-release drug delivery system (0.2 mg / d fluocinolone acetonide [FAC]) is indicated in Europe for the treatment of visual impairment associated with chronic diabetic macular edema (DME), considered to be less responsive to available therapies.

To evaluate the safety and efficacy of FAC 190-mg implant in patients with chronic refractory DME other medical treatment options in clinical settings.

Retrospective registry data was collected using a standard case report form (CRF). Prior to injection of intravitreal implant FAC, all patients were treated either with an antagonist of vascular endothelial growth factor (VEGF) and / or steroid (triamcinolone, dexamethasone implant). Patients were excluded from receiving FAC if they had a known history of an increase in intraocular pressure (IOP) after corticosteroid therapy, glaucoma, ocular hypertension, or contraindicated cited in the summary of product characteristics. Best-corrected visual acuity (BCVA) is the primary parameter studies. Central thickness of the fovea (CFT) and IOP was measured simultaneously. This parameter is recorded before and after injection of 190-mg implant FAC (between 1 week and 9 months). Injections carried out between May 2013 and March 2014.

Fifteen eyes of ten patients treated. Thirteen eyes (nine patients) were pseudophakic and seven eyes (five patients) vitrectomized before receiving treatment. BCVA improved in eleven eyes (73.3%), remained unchanged in two eyes (13.3%), and slightly decreased in the two eyes (13.3%) at the final follow-up visit to the elementary level. IOP increased in two patients and are controlled using a fixed-combination of IOP-lowering eyedrops or sectoral cyclocryotherapy (n = 1).

FAC 190-mg implant is efficacious and demonstrated favorable benefit-to-profile risk in a population of patients with chronic DME series of cases refractory to other therapy. Long-term Efficacy and safety in real-life settings is still being assessed at this center. FAC may offer important treatment option for patients with chronic refractory DME other treatment options.

 A novel intravitreal fluocinolone acetonide implant (Iluvien(®)) in the treatment of patients with chronic diabetic macular edema that is insufficiently responsive to other medical treatment options: a case series.
A novel intravitreal fluocinolone acetonide implant (Iluvien(®)) in the treatment of patients with chronic diabetic macular edema that is insufficiently responsive to other medical treatment options: a case series.

nanobeads magnetic decorated by thermo-responsive PNIPAM shell as a medical platform for the efficient delivery of doxorubicin to the tumor cells.

medical nanoplatforms based cluster superparamagnetic nanoparticles decorated with thermo-responsive PNIPAM shell has been synthesized and used as drug carriers for doxorubicin (DOXO), a common chemotherapeutic agent. The nanosystem here developed has an overall diameter below 200 nm and exploit temperature responsive behavior of PNIPAM shell polymers for controlled loading and release DOXO.

This system has been tested in vitro on tumor cells and it clearly demonstrates the effectiveness of the drug and polymer encapsulation time-dependent cell death caused by the release of doxorubicin. Mobile comparative studies of DOXO loaded nanoplatform the presence or absence of an external magnet (0.3 T) indicate a synergistic effect of accumulation and increased toxicity of the system, when magnetically guided, so that the enhanced efficacy of the system.

ProtoGlow ECL 200ml Kit

EUR 354

ProtoGlow ECL 500ml Kit

EUR 627.6

100G Acrylamide

NAT1014 100G
EUR 120

500G Acrylamide

NAT1016 500G
EUR 261.6

1KG Acrylamide

NAT1018 1KG
EUR 412.8

25G AquaPor LE

NAT1020 25G
EUR 132

100G AquaPor LE GTAC

NAT1022 100G
EUR 250.8

500G AquaPor LE GTAC

NAT1024 500G
EUR 878.4

25G AquaPor ES

NAT1026 25G
EUR 152.4

100G AquaPor ES

NAT1028 100G
EUR 350.4

25G AquaPor LM

NAT1030 25G
EUR 288

100G AquaPor LM

NAT1032 100G
EUR 860.4

25G AquaPor HR

NAT1034 25G
EUR 236.4

100G AquaPor HR

NAT1036 100G
EUR 592.8

25G AquaPor 3:1

NAT1038 25G
EUR 250.8

100G AquaPor 3:1

NAT1040 100G
EUR 570

25G Bis (Methylene Bis-Acrylamide)

NAT1042 25G
EUR 100.8

25G DATD Ultrapure

NAT1044 25G
EUR 168

250G Glycine

NAT1046 250G
EUR 94.8

1KG Glycine Ultrapure

NAT1048 1KG
EUR 128.4

250G Tris

NAT1050 250G
EUR 102

1KG Tris Ultrapure

NAT1052 1KG
EUR 177.6

100G Tricine

NAT1054 100G
EUR 120

100G Ion Exchange Resin (mixed bed)

NAT1056 100G
EUR 96

25G Riboflavin

NAT1058 25G
EUR 96


NAT1060 25ML
EUR 99.6

25G Ammonium Persulfate

NAT1062 25G
EUR 96

100G Ammonium Persulfate

NAT1064 100G
EUR 118.8

1G Dithiothreitol (DTT)

NAT1066 1G
EUR 103.2

5G Dithiothreitol (DTT)

NAT1068 5G
EUR 183.6

50ML 2-Mercaptoethanol

NAT1070 50ML
EUR 112.8

100G SDS Ultrapure

NAT1072 100G
EUR 111.6

1KG SDS Ultrapure

NAT1074 1KG
EUR 457.2

250G Urea

NAT1076 250G
EUR 98.4

1KG Urea

NAT1078 1KG
EUR 138

450ML Glycerol Ultrapure

NAT1080 450ML
EUR 132

200ML Tween 20 Ultrapure

NAT1082 200ML
EUR 132

1L Tween 20

NAT1084 1L
EUR 169.2

200ML Formamide

NAT1086 200ML
EUR 111.6

500ML Boric Acid

NAT1088 500ML
EUR 103.2


NAT1090 100G
EUR 94.8


NAT1092 500G
EUR 177.6

GelDry Film 11 X 12 cm

NAT1094 PK50
EUR 100.8

25ML Formamide CE

NAT1096 25ML Ask for price

25ML Glass Bond

NAT1098 25ML
EUR 158.4

450ML Glass Free

NAT1100 450ML
EUR 196.8

GelDry Film 22.5 X 22.5 cm

NAT1102 PK50
EUR 130.8

1L DEPC Treated Water

NAT1104 1L
EUR 120

Sterling Rapid Silver Stain Kit

NAT1106 1KIT
EUR 265.2

1L ProtoBlue Safe

NAT1108 1L
EUR 159.6

4L ProtoBlue Safe

NAT1110 4L
EUR 282

1L ProtoStain Blue

NAT1112 1L
EUR 164.4

25ML Nuclistain

NAT1114 25ML
EUR 128.4

450ML AcrylaGel 30%

NAT1116 450ML
EUR 128.4

1L AcrylaGel 30%

NAT1118 1L
EUR 177.6

450ML Bis-AcrylaGel 2%

NAT1120 450ML
EUR 98.4

1L Bis-AcrylaGel 2%

NAT1122 1L
EUR 111.6

450ML UreaGel 29:1 Concentrate

NAT1124 450ML
EUR 133.2

1L UreaGel 29:1 Concentrate

NAT1126 1L
EUR 183.6

UreaGel 29:1 System 1L Kit

EUR 171.6

UreaGel 29:1 System 2.2L Kit

EUR 253.2

450ML SequaGel UreaGel Concentrate

NAT1132 450ML
EUR 126

1L SequaGel UreaGel Concentrate

NAT1134 1L
EUR 160.8

SequaGel Sequencing System 1L Kit

NAT1136 1KIT
EUR 171.6

SequaGel Sequencing System 2.2L Kit

EUR 253.2

100ML SequaGel Buffer

NAT1140 100ML
EUR 80.4

200ML SequaGel UreaGel Buffer

NAT1142 200ML
EUR 84

450ML SequaGel UreaGel-6

NAT1144 450ML
EUR 115.2

1L SequaGel UreaGel-6

NAT1146 1L
EUR 151.2

450ML SequaGel UreaGel-8

NAT1148 450ML
EUR 115.2

1L SequaGel UreaGel-8

NAT1150 1L
EUR 151.2

450ML SequaGel UreaGel Diluent

NAT1152 450ML
EUR 90

1L SequaGel UreaGel Diluent

NAT1154 1L
EUR 103.2

90ML SequaGel Complete Buffer

NAT1156 90ML
EUR 79.2

200ML SequaGel UreaGel Complete Buffer

NAT1158 200ML
EUR 85.2

450ML SequaGel XR

NAT1160 450ML
EUR 126

1L SequaGel XR

NAT1162 1L
EUR 165.6

100ML SequaGel XR Concentrate

NAT1164 100ML
EUR 128.4

450ML SequaGel XR Concentrate

NAT1166 450ML
EUR 361.2

200ML SequaGel MD Monomer Solution

NAT1168 200ML
EUR 220.8

SequaGel MD SSCP Kit

NAT1170 1KIT
EUR 253.2

SequaGel MD Heteroduplex Kit

EUR 265.2

1.2ML SequaGel MD SSCP Stop Solution

NAT1174 1.2ML
EUR 85.2

450ML AccuGel 19:1 (30%)

NAT1176 450ML
EUR 126

1L AccuGel 19:1 (30%)

NAT1178 1L
EUR 165.6

450ML AccuGel 19:1 (40%)

NAT1180 450ML
EUR 130.8

1L AccuGel 19:1 (40%)

NAT1182 1L
EUR 168

450ML AccuGel 29:1 (30%)

NAT1184 450ML
EUR 126

1L AccuGel 29:1 (30%)

NAT1186 1L
EUR 165.6

450ML AccuGel 29:1 (40%)

NAT1188 450ML
EUR 130.8

1L AccuGel 29:1 (40%)

NAT1190 1L
EUR 168

1.2ML Triple Dye Loading Buffer (6X)

NAT1192 1.2ML
EUR 85.2

UreaGel Loading Buffer

NAT1194 10X1ML
EUR 222

1L TBE 10X

NAT1196 1L
EUR 98.4

4L TBE 10X

NAT1198 4L
EUR 145.2


NAT1200 1L
EUR 92.4


NAT1202 4L
EUR 111.6


NAT1204 25ML
EUR 98.4

25ML 10X CE Buffer

NAT1206 25ML
EUR 138

100ML 10X CE Buffer

NAT1208 100ML
EUR 196.8

450ML 20X Tris-MOPS SDS

NAT1210 450ML
EUR 130.8

450ML 20X Tris-MEPS SDS

NAT1212 450ML
EUR 130.8

1L Tris-Tricine-SDS PAGE Buffer (10X)

NAT1214 1L
EUR 217.2

1L Tris-Glycine-SDS PAGE Buffer (10X)

NAT1216 1L
EUR 105.6

4L Tris-Glycine-SDS PAGE Buffer (10X)

NAT1218 4L
EUR 148.8

1L TTE Glycerol Tolerant Buffer 20X

NAT1220 1L
EUR 160.8

1L TAE Buffer 50X

NAT1222 1L
EUR 148.8

1L SSC Buffer 20X

NAT1224 1L
EUR 98.4

4L SSC Buffer 20X

NAT1226 4L
EUR 174

100ML SDS Solution 20%

NAT1228 100ML
EUR 92.4

450ML SDS Solution 20%

NAT1230 450ML
EUR 138

1L Denaturation Solution

NAT1232 1L
EUR 102

1L Neutralization Solution

NAT1234 1L
EUR 102

50G Dextran Sulfate

NAT1236 50G
EUR 193.2

250G Dextran Sulfate

NAT1238 250G
EUR 524.4

1L Tris-Glycine Electroblotting Buffer 10X

NAT1240 1L
EUR 102

4L Tris-Glycine Electroblotting Buffer 10X

NAT1242 4L
EUR 145.2

1L TBS (10X) Tris Buffered Saline

NAT1244 1L
EUR 126

1L TBST (10X) Tris Buffered Saline w/Tween 20

NAT1246 1L
EUR 126

ProtoGel Sample Prep Kit

EUR 223.2

Protein Loading Buffer Blue 2X

NAT1250 10X1ML
EUR 105.6

Protein Loading Buffer 5X

NAT1252 10X1ML
EUR 151.2

50ML Protein Precipitation Kit

NAT1254 50ML
EUR 270

100ML ProtoLift Western Strip Buffer

NAT1256 100ML
EUR 121.2

450ML ProtoGel (30%)

NAT1258 450ML
EUR 136.8

1L ProtoGel (30%)

NAT1260 1L
EUR 187.2

450ML ProtoGel (40%)

NAT1262 450ML
EUR 157.2

1L ProtoGel (40%)

NAT1264 1L
EUR 204

450ML ProtoGel Resolving Buffer 4X

NAT1266 450ML
EUR 100.8

1L ProtoGel Resolving Buffer

NAT1268 1L
EUR 128.4

200ML ProtoGel Stacking Buffer

NAT1270 200ML
EUR 92.4

100ML ProtoGel Quick-Cast 12%

NAT1272 100ML
EUR 105.6

450ML ProtoGel Quick-Cast 12%

NAT1274 450ML
EUR 223.2

0.5ML Insite Markers

NAT1276 0.5ML
EUR 238.8

0.5ML ProtoMarkers

NAT1278 0.5ML
EUR 236.4


EUR 242.4

1L EDTA 0.5M Solution

NAT1282 1L
EUR 183.6

1L Sodium Chloride 0.009 Solution

NAT1284 1L
EUR 140.4

1L Sodium Chloride 1M Solution

NAT1286 1L
EUR 140.4

1L Potassium Chloride 1M Solution

NAT1288 1L
EUR 140.4

1L Tris-HCL 1M pH 7.2

NAT1290 1L
EUR 126

1L Tris-HCL 1M pH 7.4

NAT1292 1L
EUR 126

1L Tris-HCL 1M pH 7.6

NAT1294 1L
EUR 126


EUR 106.8


EUR 270

Mirskys Fixative (ready-to-use)

EUR 96

Mirskys Fixative (ready-to-use)

EUR 228

200ML Mirskys Fixative

NAT1304 200ML
EUR 92.4

2L Mirskys Fixative

NAT1306 2L
EUR 134.4

100ML Histomount

NAT1308 100ML
EUR 86.4

450ML Histomount

NAT1310 450ML
EUR 111.6


EUR 93.6


EUR 153.6


EUR 463.2

Calci-Clear Rapid

EUR 90

Calci-Clear Rapid

EUR 153.6

Calci-Clear Rapid

EUR 463.2

100ML Hydromount

NAT1324 100ML
EUR 110.4


EUR 136.8

100ML Omnimount

NAT1328 100ML
EUR 93.6


NAT1330 1 US gallon
EUR 184


NAT1332 5 US gallons
EUR 699.6

Histo-Clear II

NAT1334 1 US gallon
EUR 151.2

Histo-Clear II

NAT1336 5 US gallons
EUR 457.2

1L HarrisHematoxylin

NAT1338 1L
EUR 147.6

100ML Eosin Solution

NAT1340 100ML
EUR 106.8

1L Scotts Tapwater

NAT1342 1L
EUR 90

25G Alcian Blue

NAT1344 25G
EUR 194.4

25G Biebrich Scarlet

NAT1346 25G
EUR 144

25G Fast Green FCF

NAT1348 25G
EUR 192

25G Basic Fuchsin

NAT1350 25G
EUR 352.8

25G Methylene Blue

NAT1352 25G
EUR 187.2

25G Amido Black 10B

NAT1354 25G
EUR 176.4

5G Bromocresol Green

NAT1356 5G
EUR 187.2

10G Bromophenol Blue

NAT1358 10G
EUR 169.2

10G Coomassie Blue R-250

NAT1360 10G
EUR 123.6

10G Coomassie Blue G-250

NAT1362 10G
EUR 177.6

10G Methyl Green

NAT1364 10G
EUR 211.2

5G Pyronin Y

NAT1366 5G
EUR 261.6

25G Xylene Cyanol FF

NAT1368 25G
EUR 231.6

4L Hydrofluor

NAT1370 4L
EUR 200.4

4L Liquiscint

NAT1372 4L
EUR 168

4L Betafluor

NAT1374 4L
EUR 158.4

4L Monofluor

NAT1376 4L
EUR 234

4L Filtron-X

NAT1378 4L
EUR 252

Oxosol C14 Oxidizer

EUR 322.8

1L Oxosol 306

NAT1382 1L
EUR 134.4

4L Oxosol 306

NAT1384 4L
EUR 279.6

450ML Carbamate-1 CO2 Absorber

NAT1386 450ML
EUR 120

4L Ecoscint Ultra

NAT1388 4L
EUR 284.4

20L Ecoscint Ultra

NAT1390 20L
EUR 1135.2

4L Ecoscint

NAT1392 4L
EUR 205.2

20L Ecoscint

NAT1394 20L
EUR 638.4

4L Ecoscint XR

NAT1396 4L
EUR 278.4

Advances in medical treatment of various pathophysiological conditions require the development of better therapeutic agents, as well as combinations of therapeutic agents required by the integrated device biomaterials that can serve as sensors and operator. The combination of micro systems and nano-fabrication with intelligent biomaterials that have the ability to feel and response is a promising avenue for the development of better medical system diagnostic and therapeutic.