BACKGROUND
Iluvien (®) is a novel, nonbiodegradable, sustained-release drug delivery system (0.2 mg / d fluocinolone acetonide [FAC]) is indicated in Europe for the treatment of visual impairment associated with chronic diabetic macular edema (DME), considered to be less responsive to available therapies.

OBJECTIVE
To evaluate the safety and efficacy of FAC 190-mg implant in patients with chronic refractory DME other medical treatment options in clinical settings.

METHOD
Retrospective registry data was collected using a standard case report form (CRF). Prior to injection of intravitreal implant FAC, all patients were treated either with an antagonist of vascular endothelial growth factor (VEGF) and / or steroid (triamcinolone, dexamethasone implant). Patients were excluded from receiving FAC if they had a known history of an increase in intraocular pressure (IOP) after corticosteroid therapy, glaucoma, ocular hypertension, or contraindicated cited in the summary of product characteristics. Best-corrected visual acuity (BCVA) is the primary parameter studies. Central thickness of the fovea (CFT) and IOP was measured simultaneously. This parameter is recorded before and after injection of 190-mg implant FAC (between 1 week and 9 months). Injections carried out between May 2013 and March 2014.

RESULTS
Fifteen eyes of ten patients treated. Thirteen eyes (nine patients) were pseudophakic and seven eyes (five patients) vitrectomized before receiving treatment. BCVA improved in eleven eyes (73.3%), remained unchanged in two eyes (13.3%), and slightly decreased in the two eyes (13.3%) at the final follow-up visit to the elementary level. IOP increased in two patients and are controlled using a fixed-combination of IOP-lowering eyedrops or sectoral cyclocryotherapy (n = 1).

CONCLUSION
FAC 190-mg implant is efficacious and demonstrated favorable benefit-to-profile risk in a population of patients with chronic DME series of cases refractory to other therapy. Long-term Efficacy and safety in real-life settings is still being assessed at this center. FAC may offer important treatment option for patients with chronic refractory DME other treatment options.

nanobeads magnetic decorated by thermo-responsive PNIPAM shell as a medical platform for the efficient delivery of doxorubicin to the tumor cells.

medical nanoplatforms based cluster superparamagnetic nanoparticles decorated with thermo-responsive PNIPAM shell has been synthesized and used as drug carriers for doxorubicin (DOXO), a common chemotherapeutic agent. The nanosystem here developed has an overall diameter below 200 nm and exploit temperature responsive behavior of PNIPAM shell polymers for controlled loading and release DOXO.

This system has been tested in vitro on tumor cells and it clearly demonstrates the effectiveness of the drug and polymer encapsulation time-dependent cell death caused by the release of doxorubicin. Mobile comparative studies of DOXO loaded nanoplatform the presence or absence of an external magnet (0.3 T) indicate a synergistic effect of accumulation and increased toxicity of the system, when magnetically guided, so that the enhanced efficacy of the system.

ProtoGlow ECL 200ml Kit
NAT1010	National Diagnostics	EACH	EUR 354

ProtoGlow ECL 500ml Kit
NAT1012	National Diagnostics	EACH	EUR 627.6

100G Acrylamide
NAT1014	National Diagnostics	100G	EUR 120

500G Acrylamide
NAT1016	National Diagnostics	500G	EUR 261.6

1KG Acrylamide
NAT1018	National Diagnostics	1KG	EUR 412.8

25G AquaPor LE
NAT1020	National Diagnostics	25G	EUR 132

100G AquaPor LE GTAC
NAT1022	National Diagnostics	100G	EUR 250.8

500G AquaPor LE GTAC
NAT1024	National Diagnostics	500G	EUR 878.4

25G AquaPor ES
NAT1026	National Diagnostics	25G	EUR 152.4

100G AquaPor ES
NAT1028	National Diagnostics	100G	EUR 350.4

25G AquaPor LM
NAT1030	National Diagnostics	25G	EUR 288

100G AquaPor LM
NAT1032	National Diagnostics	100G	EUR 860.4

25G AquaPor HR
NAT1034	National Diagnostics	25G	EUR 236.4

100G AquaPor HR
NAT1036	National Diagnostics	100G	EUR 592.8

25G AquaPor 3:1
NAT1038	National Diagnostics	25G	EUR 250.8

100G AquaPor 3:1
NAT1040	National Diagnostics	100G	EUR 570

25G Bis (Methylene Bis-Acrylamide)
NAT1042	National Diagnostics	25G	EUR 100.8

25G DATD Ultrapure
NAT1044	National Diagnostics	25G	EUR 168

250G Glycine
NAT1046	National Diagnostics	250G	EUR 94.8

1KG Glycine Ultrapure
NAT1048	National Diagnostics	1KG	EUR 128.4

250G Tris
NAT1050	National Diagnostics	250G	EUR 102

1KG Tris Ultrapure
NAT1052	National Diagnostics	1KG	EUR 177.6

100G Tricine
NAT1054	National Diagnostics	100G	EUR 120

100G Ion Exchange Resin (mixed bed)
NAT1056	National Diagnostics	100G	EUR 96

25G Riboflavin
NAT1058	National Diagnostics	25G	EUR 96

25ML TEMED
NAT1060	National Diagnostics	25ML	EUR 99.6

25G Ammonium Persulfate
NAT1062	National Diagnostics	25G	EUR 96

100G Ammonium Persulfate
NAT1064	National Diagnostics	100G	EUR 118.8

1G Dithiothreitol (DTT)
NAT1066	National Diagnostics	1G	EUR 103.2

5G Dithiothreitol (DTT)
NAT1068	National Diagnostics	5G	EUR 183.6

50ML 2-Mercaptoethanol
NAT1070	National Diagnostics	50ML	EUR 112.8

100G SDS Ultrapure
NAT1072	National Diagnostics	100G	EUR 111.6

1KG SDS Ultrapure
NAT1074	National Diagnostics	1KG	EUR 457.2

250G Urea
NAT1076	National Diagnostics	250G	EUR 98.4

1KG Urea
NAT1078	National Diagnostics	1KG	EUR 138

450ML Glycerol Ultrapure
NAT1080	National Diagnostics	450ML	EUR 132

200ML Tween 20 Ultrapure
NAT1082	National Diagnostics	200ML	EUR 132

1L Tween 20
NAT1084	National Diagnostics	1L	EUR 169.2

200ML Formamide
NAT1086	National Diagnostics	200ML	EUR 111.6

500ML Boric Acid
NAT1088	National Diagnostics	500ML	EUR 103.2

100G EDTA
NAT1090	National Diagnostics	100G	EUR 94.8

500G EDTA
NAT1092	National Diagnostics	500G	EUR 177.6

GelDry Film 11 X 12 cm
NAT1094	National Diagnostics	PK50	EUR 100.8

25ML Formamide CE
NAT1096	National Diagnostics	25ML	Ask for price

25ML Glass Bond
NAT1098	National Diagnostics	25ML	EUR 158.4

450ML Glass Free
NAT1100	National Diagnostics	450ML	EUR 196.8

GelDry Film 22.5 X 22.5 cm
NAT1102	National Diagnostics	PK50	EUR 130.8

1L DEPC Treated Water
NAT1104	National Diagnostics	1L	EUR 120

Sterling Rapid Silver Stain Kit
NAT1106	National Diagnostics	1KIT	EUR 265.2

1L ProtoBlue Safe
NAT1108	National Diagnostics	1L	EUR 159.6

4L ProtoBlue Safe
NAT1110	National Diagnostics	4L	EUR 282

1L ProtoStain Blue
NAT1112	National Diagnostics	1L	EUR 164.4

25ML Nuclistain
NAT1114	National Diagnostics	25ML	EUR 128.4

450ML AcrylaGel 30%
NAT1116	National Diagnostics	450ML	EUR 128.4

1L AcrylaGel 30%
NAT1118	National Diagnostics	1L	EUR 177.6

450ML Bis-AcrylaGel 2%
NAT1120	National Diagnostics	450ML	EUR 98.4

1L Bis-AcrylaGel 2%
NAT1122	National Diagnostics	1L	EUR 111.6

450ML UreaGel 29:1 Concentrate
NAT1124	National Diagnostics	450ML	EUR 133.2

1L UreaGel 29:1 Concentrate
NAT1126	National Diagnostics	1L	EUR 183.6

UreaGel 29:1 System 1L Kit
NAT1128	National Diagnostics	EACH	EUR 171.6

UreaGel 29:1 System 2.2L Kit
NAT1130	National Diagnostics	EACH	EUR 253.2

450ML SequaGel UreaGel Concentrate
NAT1132	National Diagnostics	450ML	EUR 126

1L SequaGel UreaGel Concentrate
NAT1134	National Diagnostics	1L	EUR 160.8

SequaGel Sequencing System 1L Kit
NAT1136	National Diagnostics	1KIT	EUR 171.6

SequaGel Sequencing System 2.2L Kit
NAT1138	National Diagnostics	EACH	EUR 253.2

100ML SequaGel Buffer
NAT1140	National Diagnostics	100ML	EUR 80.4

200ML SequaGel UreaGel Buffer
NAT1142	National Diagnostics	200ML	EUR 84

450ML SequaGel UreaGel-6
NAT1144	National Diagnostics	450ML	EUR 115.2

1L SequaGel UreaGel-6
NAT1146	National Diagnostics	1L	EUR 151.2

450ML SequaGel UreaGel-8
NAT1148	National Diagnostics	450ML	EUR 115.2

1L SequaGel UreaGel-8
NAT1150	National Diagnostics	1L	EUR 151.2

450ML SequaGel UreaGel Diluent
NAT1152	National Diagnostics	450ML	EUR 90

1L SequaGel UreaGel Diluent
NAT1154	National Diagnostics	1L	EUR 103.2

90ML SequaGel Complete Buffer
NAT1156	National Diagnostics	90ML	EUR 79.2

200ML SequaGel UreaGel Complete Buffer
NAT1158	National Diagnostics	200ML	EUR 85.2

450ML SequaGel XR
NAT1160	National Diagnostics	450ML	EUR 126

1L SequaGel XR
NAT1162	National Diagnostics	1L	EUR 165.6

100ML SequaGel XR Concentrate
NAT1164	National Diagnostics	100ML	EUR 128.4

450ML SequaGel XR Concentrate
NAT1166	National Diagnostics	450ML	EUR 361.2

200ML SequaGel MD Monomer Solution
NAT1168	National Diagnostics	200ML	EUR 220.8

SequaGel MD SSCP Kit
NAT1170	National Diagnostics	1KIT	EUR 253.2

SequaGel MD Heteroduplex Kit
NAT1172	National Diagnostics	EACH	EUR 265.2

1.2ML SequaGel MD SSCP Stop Solution
NAT1174	National Diagnostics	1.2ML	EUR 85.2

450ML AccuGel 19:1 (30%)
NAT1176	National Diagnostics	450ML	EUR 126

1L AccuGel 19:1 (30%)
NAT1178	National Diagnostics	1L	EUR 165.6

450ML AccuGel 19:1 (40%)
NAT1180	National Diagnostics	450ML	EUR 130.8

1L AccuGel 19:1 (40%)
NAT1182	National Diagnostics	1L	EUR 168

450ML AccuGel 29:1 (30%)
NAT1184	National Diagnostics	450ML	EUR 126

1L AccuGel 29:1 (30%)
NAT1186	National Diagnostics	1L	EUR 165.6

450ML AccuGel 29:1 (40%)
NAT1188	National Diagnostics	450ML	EUR 130.8

1L AccuGel 29:1 (40%)
NAT1190	National Diagnostics	1L	EUR 168

1.2ML Triple Dye Loading Buffer (6X)
NAT1192	National Diagnostics	1.2ML	EUR 85.2

UreaGel Loading Buffer
NAT1194	National Diagnostics	10X1ML	EUR 222

1L TBE 10X
NAT1196	National Diagnostics	1L	EUR 98.4

4L TBE 10X
NAT1198	National Diagnostics	4L	EUR 145.2

1L TBE 5X
NAT1200	National Diagnostics	1L	EUR 92.4

4L TBE 5X
NAT1202	National Diagnostics	4L	EUR 111.6

25ML TE BUFFER 100X
NAT1204	National Diagnostics	25ML	EUR 98.4

25ML 10X CE Buffer
NAT1206	National Diagnostics	25ML	EUR 138

100ML 10X CE Buffer
NAT1208	National Diagnostics	100ML	EUR 196.8

450ML 20X Tris-MOPS SDS
NAT1210	National Diagnostics	450ML	EUR 130.8

450ML 20X Tris-MEPS SDS
NAT1212	National Diagnostics	450ML	EUR 130.8

1L Tris-Tricine-SDS PAGE Buffer (10X)
NAT1214	National Diagnostics	1L	EUR 217.2

1L Tris-Glycine-SDS PAGE Buffer (10X)
NAT1216	National Diagnostics	1L	EUR 105.6

4L Tris-Glycine-SDS PAGE Buffer (10X)
NAT1218	National Diagnostics	4L	EUR 148.8

1L TTE Glycerol Tolerant Buffer 20X
NAT1220	National Diagnostics	1L	EUR 160.8

1L TAE Buffer 50X
NAT1222	National Diagnostics	1L	EUR 148.8

1L SSC Buffer 20X
NAT1224	National Diagnostics	1L	EUR 98.4

4L SSC Buffer 20X
NAT1226	National Diagnostics	4L	EUR 174

100ML SDS Solution 20%
NAT1228	National Diagnostics	100ML	EUR 92.4

450ML SDS Solution 20%
NAT1230	National Diagnostics	450ML	EUR 138

1L Denaturation Solution
NAT1232	National Diagnostics	1L	EUR 102

1L Neutralization Solution
NAT1234	National Diagnostics	1L	EUR 102

50G Dextran Sulfate
NAT1236	National Diagnostics	50G	EUR 193.2

250G Dextran Sulfate
NAT1238	National Diagnostics	250G	EUR 524.4

1L Tris-Glycine Electroblotting Buffer 10X
NAT1240	National Diagnostics	1L	EUR 102

4L Tris-Glycine Electroblotting Buffer 10X
NAT1242	National Diagnostics	4L	EUR 145.2

1L TBS (10X) Tris Buffered Saline
NAT1244	National Diagnostics	1L	EUR 126

1L TBST (10X) Tris Buffered Saline w/Tween 20
NAT1246	National Diagnostics	1L	EUR 126

ProtoGel Sample Prep Kit
NAT1248	National Diagnostics	EACH	EUR 223.2

Protein Loading Buffer Blue 2X
NAT1250	National Diagnostics	10X1ML	EUR 105.6

Protein Loading Buffer 5X
NAT1252	National Diagnostics	10X1ML	EUR 151.2

50ML Protein Precipitation Kit
NAT1254	National Diagnostics	50ML	EUR 270

100ML ProtoLift Western Strip Buffer
NAT1256	National Diagnostics	100ML	EUR 121.2

450ML ProtoGel (30%)
NAT1258	National Diagnostics	450ML	EUR 136.8

1L ProtoGel (30%)
NAT1260	National Diagnostics	1L	EUR 187.2

450ML ProtoGel (40%)
NAT1262	National Diagnostics	450ML	EUR 157.2

1L ProtoGel (40%)
NAT1264	National Diagnostics	1L	EUR 204

450ML ProtoGel Resolving Buffer 4X
NAT1266	National Diagnostics	450ML	EUR 100.8

1L ProtoGel Resolving Buffer
NAT1268	National Diagnostics	1L	EUR 128.4

200ML ProtoGel Stacking Buffer
NAT1270	National Diagnostics	200ML	EUR 92.4

100ML ProtoGel Quick-Cast 12%
NAT1272	National Diagnostics	100ML	EUR 105.6

450ML ProtoGel Quick-Cast 12%
NAT1274	National Diagnostics	450ML	EUR 223.2

0.5ML Insite Markers
NAT1276	National Diagnostics	0.5ML	EUR 238.8

0.5ML ProtoMarkers
NAT1278	National Diagnostics	0.5ML	EUR 236.4

ProtoMetrics
NAT1280	National Diagnostics	EACH	EUR 242.4

1L EDTA 0.5M Solution
NAT1282	National Diagnostics	1L	EUR 183.6

1L Sodium Chloride 0.009 Solution
NAT1284	National Diagnostics	1L	EUR 140.4

1L Sodium Chloride 1M Solution
NAT1286	National Diagnostics	1L	EUR 140.4

1L Potassium Chloride 1M Solution
NAT1288	National Diagnostics	1L	EUR 140.4

1L Tris-HCL 1M pH 7.2
NAT1290	National Diagnostics	1L	EUR 126

1L Tris-HCL 1M pH 7.4
NAT1292	National Diagnostics	1L	EUR 126

1L Tris-HCL 1M pH 7.6
NAT1294	National Diagnostics	1L	EUR 126

Histosol
NAT1296	National Diagnostics	EACH	EUR 106.8

Histosol
NAT1298	National Diagnostics	EACH	EUR 270

Mirskys Fixative (ready-to-use)
NAT1300	National Diagnostics	1USGALLON	EUR 96

Mirskys Fixative (ready-to-use)
NAT1302	National Diagnostics	EACH	EUR 228

200ML Mirskys Fixative
NAT1304	National Diagnostics	200ML	EUR 92.4

2L Mirskys Fixative
NAT1306	National Diagnostics	2L	EUR 134.4

100ML Histomount
NAT1308	National Diagnostics	100ML	EUR 86.4

450ML Histomount
NAT1310	National Diagnostics	450ML	EUR 111.6

Calci-Clear
NAT1312	National Diagnostics	EACH	EUR 93.6

Calci-Clear
NAT1314	National Diagnostics	EACH	EUR 153.6

Calci-Clear
NAT1316	National Diagnostics	EACH	EUR 463.2

Calci-Clear Rapid
NAT1318	National Diagnostics	EACH	EUR 90

Calci-Clear Rapid
NAT1320	National Diagnostics	EACH	EUR 153.6

Calci-Clear Rapid
NAT1322	National Diagnostics	EACH	EUR 463.2

100ML Hydromount
NAT1324	National Diagnostics	100ML	EUR 110.4

Neutralin
NAT1326	National Diagnostics	5USGALLON	EUR 136.8

100ML Omnimount
NAT1328	National Diagnostics	100ML	EUR 93.6

Histo-Clear
NAT1330	National Diagnostics	1 US gallon	EUR 184

Histo-Clear
NAT1332	National Diagnostics	5 US gallons	EUR 699.6

Histo-Clear II
NAT1334	National Diagnostics	1 US gallon	EUR 151.2

Histo-Clear II
NAT1336	National Diagnostics	5 US gallons	EUR 457.2

1L HarrisHematoxylin
NAT1338	National Diagnostics	1L	EUR 147.6

100ML Eosin Solution
NAT1340	National Diagnostics	100ML	EUR 106.8

1L Scotts Tapwater
NAT1342	National Diagnostics	1L	EUR 90

25G Alcian Blue
NAT1344	National Diagnostics	25G	EUR 194.4

25G Biebrich Scarlet
NAT1346	National Diagnostics	25G	EUR 144

25G Fast Green FCF
NAT1348	National Diagnostics	25G	EUR 192

25G Basic Fuchsin
NAT1350	National Diagnostics	25G	EUR 352.8

25G Methylene Blue
NAT1352	National Diagnostics	25G	EUR 187.2

25G Amido Black 10B
NAT1354	National Diagnostics	25G	EUR 176.4

5G Bromocresol Green
NAT1356	National Diagnostics	5G	EUR 187.2

10G Bromophenol Blue
NAT1358	National Diagnostics	10G	EUR 169.2

10G Coomassie Blue R-250
NAT1360	National Diagnostics	10G	EUR 123.6

10G Coomassie Blue G-250
NAT1362	National Diagnostics	10G	EUR 177.6

10G Methyl Green
NAT1364	National Diagnostics	10G	EUR 211.2

5G Pyronin Y
NAT1366	National Diagnostics	5G	EUR 261.6

25G Xylene Cyanol FF
NAT1368	National Diagnostics	25G	EUR 231.6

4L Hydrofluor
NAT1370	National Diagnostics	4L	EUR 200.4

4L Liquiscint
NAT1372	National Diagnostics	4L	EUR 168

4L Betafluor
NAT1374	National Diagnostics	4L	EUR 158.4

4L Monofluor
NAT1376	National Diagnostics	4L	EUR 234

4L Filtron-X
NAT1378	National Diagnostics	4L	EUR 252

Oxosol C14 Oxidizer
NAT1380	National Diagnostics	EACH	EUR 322.8

1L Oxosol 306
NAT1382	National Diagnostics	1L	EUR 134.4

4L Oxosol 306
NAT1384	National Diagnostics	4L	EUR 279.6

450ML Carbamate-1 CO2 Absorber
NAT1386	National Diagnostics	450ML	EUR 120

4L Ecoscint Ultra
NAT1388	National Diagnostics	4L	EUR 284.4

20L Ecoscint Ultra
NAT1390	National Diagnostics	20L	EUR 1135.2

4L Ecoscint
NAT1392	National Diagnostics	4L	EUR 205.2

20L Ecoscint
NAT1394	National Diagnostics	20L	EUR 638.4

4L Ecoscint XR
NAT1396	National Diagnostics	4L	EUR 278.4

Advances in medical treatment of various pathophysiological conditions require the development of better therapeutic agents, as well as combinations of therapeutic agents required by the integrated device biomaterials that can serve as sensors and operator. The combination of micro systems and nano-fabrication with intelligent biomaterials that have the ability to feel and response is a promising avenue for the development of better medical system diagnostic and therapeutic.