Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis Poorly Responsive to Medical Treatment.
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Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis Poorly Responsive to Medical Treatment.
OBJECTIVE To evaluate the success (eradication of infection) or failure (recurrence of infection in the cornea or sclera, or endophthalmitis) of the initial therapy anterior lamellar keratoplasty (DALK) for active Acanthamoeba keratitis (AK) is less responsive to medical treatment.
METHOD Retrospective, noncomparative case series of 11 patients (11 eyes) affected by the active AK less responsive to treatment who underwent DALK start of therapy. Surgery was performed in all cases within 30 to 60 days of onset of symptoms. corneal ulcer depth is less than 300 m in all cases. 3-drug combination (chlorhexidine gluconate, isethionate propamidine and neomycin sulfate) is antiamoebic protocol used preoperatively and postoperatively. Cannula large bubbles and “layer by layer” do the dissection technique. Eradication of infection, rejection episodes, postoperative endothelial cell density, and the best spectacle-corrected visual acuity were evaluated. Histological examination of surgical margins is done, and the margin permission rated. Average follow-up was approximately 2 years.
RESULTS Four DALK descemetic and 7 DALK predescemetic do. One small Descemet membrane rupture occurs. peripheral surgical margins free of infection in all cases. deep surgical margins are not free of the infection was found in 2 cases. However, there is no recurrence of infection episodes was observed. The average postoperative best spectacle-corrected visual acuity was 0.8 (range, 0.6 to 1.0). No cases of refusal was recorded.
CONCLUSION DALK initial therapy can be considered as a new approach to combat an active infection in the case of AK less responsive to treatment, with significant ulcer in the optical zone. Further studies are needed to validate this new indication for DALK.
Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis Poorly Responsive to Medical Treatment.
Culture responsive integrated health care: Key issues for medical education.
Primary care providers increasingly responsible for providing mental health care in the United States. For patients who received specialized mental health services, primary care providers function as the major entry point into the mental health system.
Given the persistent racial and ethnic health disparities in the United States, it is not surprising that the mental health gap also presents a difficult challenge for both the US healthcare system and front line practitioners. Doctors-in-training need psychiatric evaluation tool for fast that will quickly identify the cluster of symptoms is concerned and distinguish between major psychological disorders.
It is the obligation of residency faculty to teach medical residents how to provide culturally responsive mental health assessment and intervention / referral knowledge and skills towards the elimination of this gap and toward patient-centered care. This article begins with an overview of health inequalities and barriers to health and access to mental health care, followed by a discussion of cultural responsive care, including examples of educational programs responsive culture in the United States that directly target the problem of access within a geographic area.
Description: CRK, also known as p38, is a protein that in humans is encoded by the CRK gene. This gene is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It is mapped to 17p13.3. The protein participates in the Reelin signaling cascade downstream of DAB1. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of Crk functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Description: This recombinant p38 antibody reacts to human p38 MAPK. It may also react to the rat and mouse protein, as predicted by immunogen homology.
Description: P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Description: P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is unconjugated.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is unconjugated.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 390.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 488.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 565.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 594.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 633.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 655.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 680.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 700.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Alkaline Phosphatase.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to APC .
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to APC/Cy7.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Biotin.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 350.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 405.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 488.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 594.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 633.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to FITC.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to HRP.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to PE/ATTO 594.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to PerCP.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to RPE .
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Streptavidin.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is unconjugated.
MAPK P38 ELISA Kit| Mouse P38 Mitogen-activated Protein Kinase E
Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each.
Description: MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Description: MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. It has been implicated in various cancer pathologies and depending on the context, can facilitate or interfere with tumor development, and therefore has immense potential therapeutic interest.
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. It has been implicated in various cancer pathologies and depending on the context, can facilitate or interfere with tumor development, and therefore has immense potential therapeutic interest.
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. It has been implicated in various cancer pathologies and depending on the context, can facilitate or interfere with tumor development, and therefore has immense potential therapeutic interest.
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. It has been implicated in various cancer pathologies and depending on the context, can facilitate or interfere with tumor development, and therefore has immense potential therapeutic interest.
Description: Mitogen-activated protein kinase 12 (MAP kinase 12), also known as p38 gamma, extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene. Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
Description: A polyclonal antibody for detection of p38 MAPK from Human, Mouse, Rat. This p38 MAPK antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human p38 MAPK protein
Description: A polyclonal antibody for detection of p38 MAPK from Human, Mouse, Rat. This p38 MAPK antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human p38 MAPK protein
Description: A polyclonal antibody for detection of p38 MAPK from Human, Mouse, Rat. This p38 MAPK antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human p38 MAPK protein
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MAPK14 / p38 . This antibody is tested and proven to work in the following applications:
Description: The substance JX 401 is a p38 map kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml).
Description: The substance JX 401 is a p38 map kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is off-white solid which is soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml).
It concludes with a review of educational strategies to improve mental health services responsive behavior and culture by doctors in training. This review was organized by organ system, each section includes a brief discussion with reference to more in-depth discussion in other sources. A number of algorithms including to determine the approach to the evaluation of common clinical presentation that can help doctors treat this population in the setting of acute or subacute.
