Long-term benefit of transoral incisionless fundoplication using the esophyx device for the management of gastroesophageal reflux disease responsive to medical therapy.

Incisionless transoral fundoplication (TIF) using EsophyX device has been proven effective and safe in patients with Gastroesophageal reflux disease (GERD); However, a subset of patients who will mostly benefit from this technique is still unknown. The purpose of this study was to evaluate the long-term efficacy and safety of TIF procedure in patients with a history of chronic esophagitis or proven GERD symptoms who have achieved control with the administration of proton pump inhibitors (PPI) but do not want to continue receiving medication for life.

Forty-five patients with typical GERD symptoms (heartburn, regurgitation, chest pain) and a history of esophagitis grade A and B or proven GERD with esophageal pH monitoring underwent TIF using Esophyx. Patients with eosphagitis C and D or those with large hiatal hernia (> 2 cm) were excluded. Clinical primary efficacy measure was the elimination of GERD symptoms at follow-up based on the normalization of GERD health-related quality of life (GERD-HRQL) questionnaire.

After a median follow-up period of 59 months (36-75) GERD-HRQL score improved significantly from a median of 27 (2-45) at baseline to 4 (0-26) (P <0.001) in the 44 patients completed the study. Heartburn eliminated in 12 of 21 patients included (57.1%), regurgitation were eliminated in 15 of the 17 patients included (88.2%) and chest pain eventually eliminated in five of six patients including patients (83.3%). Overall, 32 patients out of 44 patients (72.7%) who completed the follow-up study reported elimination of their main symptoms, without the need for administration of PPI (no use of PPIs).

Furthermore, six patients (13.6%), five with heartburn, regurgitation and one with a reported half-dose PPI is taken to <50% from the previous follow-up period (PPI use occasionally), while six patients (four with heartburn, one with regurgitation, and one with chest pain) reported full or half-dose PPI is taken for more than 50% from the previous follow-up period (PPI use every day). The creation of an esophagogastric fundoplication using EsophyX device abolished reflux symptoms in 72.7% of patients with GERD is PPI-responsive at a median of 59 months follow-up.

Long-term benefit of transoral incisionless fundoplication using the esophyx device for the management of gastroesophageal reflux disease responsive to medical therapy.
Long-term benefit of transoral incisionless fundoplication using the esophyx device for the management of gastroesophageal reflux disease responsive to medical therapy.

Responsive to the diversity of medical education: taking intersectionality based approach to curriculum evaluation.

Recent years have seen an increase in efforts to implement a variety of topics to medical education, using either the ‘narrowing down’ or the definition of ‘widespread’ culture. This development is encouraging that the results of such efforts are systematically evaluated by mapping the curriculum for diversity-responsive content.

This study aims to use intersectionality based approach to determine the learning objectives related to diversity-and to evaluate how the biomedical and social aspects of cultural diversity are integrated into the medical curriculum in the Netherlands. We took a three-phase mixed methods approach.

In phase one and two, we define essential learning objectives based on qualitative interviews with school stakeholders and literary diversity. In phase three, we screened for content written curriculum diversity (culture, sex / gender and class) and associated outcomes with the objectives set in the two-phase study. We identified three learning objectives in the field of education (medical knowledge and skills, patient-physician communication, and reflexivity).

MM-102

B1582-2 2 mg
EUR 128
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-20 20 mg
EUR 593
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-5 5 mg
EUR 212
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B2364-25
EUR 588

MM-102

B2364-5
EUR 185

PPQ-102

B3504-10 10 mg
EUR 242

PPQ-102

B3504-5 5 mg
EUR 151

PPQ-102

B3504-50 50 mg
EUR 863

PM 102

B5517-1 1 mg
EUR 601

MM-102

HY-12220 10mg
EUR 298

IAXO-102

HY-125171 50mg
EUR 1944

PPQ-102

HY-14179 100mg
EUR 1221

BGB-102

HY-15732 10mg
EUR 6041

EL-102

HY-16187 10mM/1mL
EUR 376

LSZ-102

HY-111486 50mg
EUR 3321

p38 Antibody

35478-100ul 100ul
EUR 390

p38 Antibody

48644-100ul 100ul
EUR 333

p38 Antibody

48644-50ul 50ul
EUR 239

p38 antibody

70R-51505 100 ul
EUR 268
Description: Purified Polyclonal p38 antibody

p38 antibody

70R-51506 100 ul
EUR 287
Description: Purified Polyclonal p38 antibody

p38 Antibody

20-abx007541
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Antibody

20-abx133223
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Antibody

20-abx141038
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 protein

E20-80078 20ug
EUR 408

p38 protein

E20-80079 20ug
EUR 408

p38 Antibody

abx236076-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

anti-p38

YF-PA11120 50 ug
EUR 363
Description: Mouse polyclonal to p38

anti-p38

YF-PA11121 100 ug
EUR 403
Description: Rabbit polyclonal to p38

anti-p38

YF-PA23519 50 ul
EUR 334
Description: Mouse polyclonal to p38

anti-p38

YF-PA23520 50 ul
EUR 334
Description: Mouse polyclonal to p38

anti-p38

YF-PA23521 50 ul
EUR 334
Description: Mouse polyclonal to p38

LB (Lennox)

102 500 g
EUR 101

BP-1-102

HY-100493 100mg
EUR 1345

MM-102 (TFA)

HY-12220A 10mM/1mL
EUR 263

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor

E1B1863 1mg
EUR 161

P38 delta protein

30R-2868 5 ug
EUR 503
Description: Purified recombinant Human P38 delta protein

p38 alpha protein

30R-2870 5 ug
EUR 503
Description: Purified recombinant Human p38 alpha protein

p38 beta protein

30R-2875 5 ug
EUR 503
Description: Purified recombinant Human p38 beta protein

p38 MAPK antibody

20R-1572 100 ug
EUR 705
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody

20R-2087 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2088 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2403 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

p38 MAPK antibody

20R-2950 100 ul
EUR 393
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

10R-8422 100 ul
EUR 393
Description: Mouse monoclonal p38 MAPK antibody

p38 MAPK Antibody

49379-100ul 100ul
EUR 333

p38 MAPK Antibody

49379-50ul 50ul
EUR 239

p38 Polyclonal Antibody

41305-100ul 100ul
EUR 252

p38 Polyclonal Antibody

41305-50ul 50ul
EUR 187

p38 Polyclonal Antibody

41306-100ul 100ul
EUR 252

p38 Polyclonal Antibody

41306-50ul 50ul
EUR 187

Anti-p38 alpha

DB-1039 100 tests
EUR 474

Anti-p38 beta

DB-1040 100 tests
EUR 474

Anti-p38 gamma

DB-1041 100 tests
EUR 474

Anti-p38 delta

DB-1042 100 tests
EUR 474

Anti-p38-a

DB-161-0.05 50 μl
EUR 269

Anti-p38-a

DB-161-0.1 100 μl
EUR 422

Anti-p38-b

DB-162-0.05 50 μl
EUR 269

Anti-p38-b

DB-162-0.1 100 μl
EUR 422

Anti-p38-g

DB-163-0.05 50 μl
EUR 269

Anti-p38-g

DB-163-0.1 100 μl
EUR 422

Anti-p38-d

DB-164-0.05 50 μl
EUR 269

Anti-p38-d

DB-164-0.1 100 μl
EUR 422

Anti-p38 alpha

DB1039 100 tests
EUR 474

Anti-p38 beta

DB1040 100 tests
EUR 474

Anti-p38 gamma

DB1041 100 tests
EUR 474

Anti-p38 delta

DB1042 100 tests
EUR 474

p38 beta, Active

7763-100
EUR 4345

p38 beta, Active

7763-5
EUR 370

Anti-p38 Antibody

A00176 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.

p38 MAPK antibody

70R-33398 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

70R-33400 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody

70R-34325 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

70R-34327 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody

p38 (pT180) Antibody

20-abx009863
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 (pY323) Antibody

20-abx133058
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 (pY182) Antibody

20-abx134951
  • EUR 384.00
  • EUR 606.00
  • EUR 230.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Blocking Peptide

20-abx161932
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 MAPK Antibody

20-abx012798
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

p38 MAPK Antibody

20-abx012875
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

p38 Blocking Peptide

20-abx061736
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 Blocking Peptide

20-abx062080
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 MAPK Antibody

AF6455 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

AF6456 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

AF6457 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

abx236077-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

p38 Polyclonal Antibody

ABP53838-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53839-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 MAPK Antibody

ABF6456 100 ug
EUR 438

p38 Polyclonal Antibody

ABP52112-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52113-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP57354-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

Most content classified diversity of biomedical knowledge and skills. the limited attention given to social and cultural issues as determinants of health and health care use.